TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson’s Disease with Opposite Effects

Restless Legs Syndrome Prevalence in Major Thalasemia Tabriz Children Hospital

Sensory profile in primary restless legs syndrome and restless legs syndrome associated with small fibre neuropathy.

Sir, The association of restless legs syndrome with polyneuropathy, especially with involvement of small sensory fibres, is suggested by several observations (Iannaccone et al., 1995; Polydefkis et al., 2000; Gemignani et al., 2006); however, it is still controversial (Hattan et al., 2009). Bachmann et al. (2010) investigated 34 consecutive outpatients with restless legs syndrome from their Mov...

Restless legs syndrome in a person with Fahr's disease.

B striato-pallido-dentate calcinosis (Fahr’s disease) is known as bilateral symmetric calcification, mainly of the basal ganglia and the dentate nucleus of the cerebellum.1 The clinical features can be varied. The diagnosis is established by CT or MRI of brain and ruling out calcium metabolism abnormalities and developmental defects. Restless legs syndrome (RLS) is a common neurological sensori...

The restless legs syndrome.

The first description of the restless legs syndrome (RLS) is attributed to Thomas Willis in the 'London Practice of Physick' of 1685 (Ekbom, 1960). Here he wrote 'wherefore to some, when being a bed they betake themselves to sleep, presently in the arms and leggs, leapings and contractions of their tendons, and so great a restlessness and tossings of their members ensue, that the diseased are n...

Restless legs syndrome.

Restless legs syndrome is common; it is characterised by an urge to move and usually, but not exclusively, affects the legs. This urge to move is typically accompanied by abnormal sensations, variably described as burning, tingling, aching, or “insects crawling under the skin.” These sensations are transiently or partially relieved by movement, and there is a strong circadian influence—symptoms...